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KMID : 0861020010160020007
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Korea Journal of Herbology
2001 Volume.16 No. 2 p.7 ~ p.12
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Vasodilation Effect of the Ginkgo Folium Water Extract on isolated Rat Thoracic Aorta
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Jang Jun-Bock
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Abstract
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We have examined the relaxational response of the Ginkgo Folium water extract on isolated thoracic aorta from sprague dawley rat (300~350g) in the presence and absence of endothelium and the vasodilator nitric oxide. Segments of thoracic aorta obtained from rats immediately after delivery were mounted in organ baths superfused on a polygraph.
We found that the thoracic aorta segments responded to the Ginkgo Folium water extract with a dose-dependent vasorelaxation. At 2.0 ㎎/㎖ Ginkgo Folium water extract, the relaxational response with and without endothelium were 75.8% and 6.9% of the maximum KCI-response. The Phenylepinephrine and 5-hydroxytrptamine - induced contraction at 10^-4M were inhibited by 77.3% and 75.8% after addition(2.0 ㎎/㎖) of the Ginkgo Folium water extract. After pre-treatment of the thoracic aorta with N^G-monomethyl-L-arginine(10^-4M), the vessels contracted in response to the nitric oxide synthase inhibitor. The present results show that nitric oxide may act as a crucial signal in the vasodilative action.
In conclusion, Ginkgo Folium water extract-induced relaxation in the isolated rat thoracic aorta was composed of endothelium-dependent and dose-dependent relaxation. Endothelium-dependent relaxation may be mediated by release of endothelium derived relaxing factor, nitric oxide.
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